Hexosaminidase-altered Aberrant Crypts, Carrying Decreased Hexosaminidase α and β Subunit mRNAs, in Colon of 1,2-Dimethylhydrazine-treated Rats
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چکیده
منابع مشابه
Monocyte Secretion of β-Hexosaminidase in Patients With Obstructive Jaundice
Monocyte hydrolases are harmful when secreted inappropriately. In this study we have investigated the levels of one of the hydrolases. beta-hexosaminidase in patients with obstructive jaundice. These patients showed markedly elevated plasma levels, and their monocytes show increased spontaneous secretion and total enzyme content. The plasma enzyme levels correlate with monocyte enzyme content a...
متن کاملN-acetyl-β-hexosaminidase in chronic tonsillitis and tonsillar hypertrophy.
BACKGROUND The concentration and specific activity of N-acetyl-β-hexosaminidase (HEX) in palatine tonsils with chronic tonsillitis and tonsillar hypertrophy give insight in tonsillar tissue remodeling and constitute a potential marker for diagnosis and treatment of chronic tonsillitis and tonsillar hypertrophy. AIM Determining the concentration and specific activity of N-acetyl-β-hexosaminida...
متن کاملRole of N-acetyl-β-d-hexosaminidase in cholesteatoma tissue
Cholesteatoma is a destructive disease characterized by the progressive expansion of keratinizing squamous epithelium in the middle ear and mastoid, and chronic inflammatory reaction of the subepithelial connective tissue. N-Acetyl-β-d-hexosaminidase (HEX) catalyzes the release of terminal non-reducing N-acetyl-d-hexosamine residues acting on glucosides and galactosides in glycoproteins, GM2-ga...
متن کاملImmunochemical and biochemical investigation of hexosaminidase S.
Hexosaminidase S (HEX S), the residual isozyme found in tissues and body fluids of children with the O variant of GM2 gangliosidosis, was purified from tissues of variant individuals and biochemically and immunochemically characterized. This enzyme has an apparent molecular weight of 103,000 with an isoelectric point of 4.2, is heat labile to the same extent as HEX A, and loses most of its acti...
متن کاملDoes β-hexosaminidase function only as a degranulation indicator in mast cells? The primary role of β-hexosaminidase in mast cell granules.
β-Hexosaminidase, which is generally present in the lysosome, is essential for glycoprotein metabolism in the maintenance of cell homeostasis. In mast cells (MCs), large amounts of β-hexosaminidase are present in the granules as opposed to the lysosome, and the biological role of MC β-hexosaminidase has yet to be fully elucidated. Therefore, we investigated the biological role of β-hexosaminida...
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 2001
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.2001.tb01072.x